Intermediate structure of normal human haemoglobin: Methaemoglobin in the deoxy quaternary conformation
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چکیده
منابع مشابه
Intermediate structure of normal human haemoglobin: methaemoglobin in the deoxy quaternary conformation.
This paper describes E new method of producing a crystalline intermediate between the unligated and ligated states of haemoglobin, suitable for X-ray analysis, by the use of a lattice strengthening reagent. Acrylamide is polymerized in the liquid of crystallization after the crystal haa grown, forming a stiff supporting gel between the haemoglobin molecules, but not covalent bonds with them. Th...
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Haemoglobin Kansas (Asn102(G4)/? + Thr) is the only widely studied mutant or modified haemoglobin having four functional haems and displaying lower than normal oxygen aBnity. Two forms of this mutant have been investigated by X-ray diffraction. The deoxy form, whose crystals are isomorphous with the native form, has been examined directly by the difference Fourier technique (3.4 A). In addition...
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We report the X-ray crystal structure of two analogues of human haemoglobin in the deoxy quaternary (T) state with ligand bound exclusively at the alpha haems. These models were prepared from symmetric, mixed-metal hybrid haemoglobin molecules. The structures of alpha Fe(II) beta Co(II), its carbonmonoxy derivative alpha Fe(II)CO beta Co(II), and alpha Fe(II)O2 beta Ni(II) are compared with nat...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 1973
ISSN: 0022-2836
DOI: 10.1016/0022-2836(73)90401-4